Study summary

The purpose of this study is to confirm the recommended phase 2 dose (RP2D) of zolbetuximab in combination with Nab-P + GEM, determine overall survival and assess the safety and tolerability of the combination treatment.

This study will also evaluate tumor markers and pharmacokinetics (PK) of zolbetuximab, Nab-P and GEM, and health-related quality of life (HRQoL).

Additional Study Details

Phase
Phase 2
Product
zolbetuximab
Product
  • zolbetuximab
  • nab-paclitaxel
  • gemcitabine
  • Type
    Interventional
    Masking
    None (Open Label)
    Enrollment number
    393
    Show Additional Study Details

    Get more information

    Would you like more information about clinical trial sites that are recruiting participants for A Study to Assess the Efficacy and Safety of IMAB362 in Combination with Nab-Paclitaxel and Gemcitabine (Nab-P + GEM) as First Line Treatment in Subjects with Claudin 18.2 (CLDN18.2) Positive, Metastatic Pancreatic Adenocarcinoma? Contact us by filling out your information to the right and we’ll respond to you.

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    • Algeria
    • Argentina
    • Armenia
    • Australia
    • Austria
    • Belarus
    • Belgium
    • Bosnia And Herzegovina
    • Brazil
    • Bulgaria
    • Canada
    • Chile
    • China
    • Colombia
    • Croatia
    • Czech Republic
    • Denmark
    • Dominican Republic
    • Egypt
    • Estonia
    • Finland
    • Former Serbia and Montenegro
    • France
    • Georgia
    • Germany
    • Greece
    • Guatemala
    • Hong Kong
    • Hungary
    • Iceland
    • India
    • Indonesia
    • Ireland
    • Israel
    • Italy
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    • Jordan
    • Kazakhstan
    • Latvia
    • Lebanon
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    • Macedonia
    • Malaysia
    • Mexico
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    • Netherlands
    • New Zealand
    • Norway
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    • Peru
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    • Thailand
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    • Ukraine
    • United Kingdom
    • United States
    • Vietnam

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      Locations

      Contact Us
      Contact Us
      Active, not recruiting
      Memorial Sloan-Kettering Cancer Center
      New York, NY, United States, 10022
      Active, not recruiting
      Site JP81007
      Nagoya, Aichi, Japan
      Active, not recruiting
      Site FR33010
      Brest, Brest Cedex, France, 9GV7+4G
      Active, not recruiting
      Site JP81006
      Yokohama, Kanagawa, Japan
      Completed
      Site ES34005
      Lleida, Lleida, Spain, 25198
      Completed
      Ochsner Health System
      New Orleans, LA, United States, 70121
      Completed
      Site ES34014
      Caceres, Caceres, Spain, 10003
      Withdrawn
      University of Kansas Cancer Center
      Westwood, KS, United States, 66205
      Withdrawn
      Cancer Treatment Centers of America, Chicago
      Zion, IL, United States, 60099
      Active, not recruiting
      Site IT39003
      Milan, Milan, Italy, 20141
      Completed
      Lynn Cancer Institute
      Boca Raton, Florida, United States, 33486
      Completed
      Site ES34004
      Llobregat, Barcelona, Spain, 08908
      Completed
      Site FR33008
      Besancon, Besancon Cedex, France, 6XG7+42
      Completed
      Northwell Health Cancer Institute
      Lake Success, NY, United States, 11042
      Active, not recruiting
      Site JP81004
      Fukuoka, Fukuoka, Japan
      Completed
      Baptist Health
      Miami, FL, United States, 33176
      Completed
      Site AU61008
      Gosford, New South Wales, Australia, NSW 2250
      Withdrawn
      Mercy Clinic Oklahoma Communities, Inc
      Oklahoma City, OK, United States, 73120
      Completed
      Site JP81005
      Sapporo, Hokkaido, Japan
      Completed
      Site IT39004
      Candiolo, Torino, Italy, 10060
      Active, not recruiting
      Site KR82002
      Seoul, Seoul, Republic of Korea, F3QP+76
      Active, not recruiting
      Site ES34013
      Barcelona, Barcelona, Spain, 08036
      Withdrawn
      PMG Research of McFarland Clinic
      Ames, IA, United States, 50010
      Withdrawn
      Site FR33004
      Saint-Étienne, Cedex 02, France, 42000
      Active, not recruiting
      Site JP81011
      Bunkyo-ku, Tokyo, Japan
      Withdrawn
      Site TW88607
      Tainan City, Liuying District, Taiwan, Province of China, 73657
      Withdrawn
      Cancer Treatment Centers of Phoenix
      Goodyear, AZ, United States, 85338
      Active, not recruiting
      Site FR33003
      Aquitaine, Pessac, France, 33604
      Completed
      Site KR82001
      Seoul, Seoul, Republic of Korea, 03080
      Active, not recruiting
      Site KR82005
      Seongnam-Si, Gyeonggi-do, Republic of Korea, 013620
      Active, not recruiting
      Site KR82003
      Seoul, Seoul, Republic of Korea, 120-752
      Completed
      Site ES34015
      Madrid, Madrid, Spain, 28027
      Active, not recruiting
      Site KR82006
      Seoul, Seoul, Republic of Korea, G234+36
      Completed
      Site ES34009
      Madrid, Madrid, Spain, 28034
      Withdrawn
      Our Lady of the Lake
      Baton Rouge, LA, United States, 70809
      Completed
      Site FR33017
      Rouen, Normandy, France, 76000
      Withdrawn
      Site ES34012
      Madrid, Madrid, Spain, 28046
      Withdrawn
      Scott and White Memorial Hospital
      Temple, TX, United States, 76508
      Withdrawn
      Site ES34008
      Madrid, Madrid, Spain, 28050
      Active, not recruiting
      Site IR35301
      Elm Park, Dublin, Ireland, D04 T6F4
      Completed
      Site AU61007
      Wollongong, New South Wales, Australia, HVGM+3C
      Completed
      Site ES34006
      Madrid, Madrid, Spain, 28033
      Active, not recruiting
      Site FR33009
      Nancy, Nancy Cedex, France, 54000
      Active, not recruiting
      Site KR82007
      Seoul, Seoul, Republic of Korea, 152-703
      Withdrawn
      UCLA Hematology Oncology
      Santa Monica, CA, United States, 90404
      Completed
      TOI Clinical research
      Whittier, CA, United States, 90603
      Completed
      David C Pratt Cancer Center
      Creve Coeur, Mo, United States, 63141
      Active, not recruiting
      Site FR33015
      Caen, Cedex 5, France, 14076
      Active, not recruiting
      Houston Methodist Hospital
      Houston, TX, United States, 77030
      Completed
      Site IT39002
      Cremona, Cremona, Italy, 26100
      Completed
      Site FR33006
      Chambray, cedex 9, France, 37170
      Withdrawn
      Site ES34016
      Madrid, Madrid, Spain, 28027
      Completed
      Site ES34007
      Barcelona, Barcelona, Spain, 08916
      Active, not recruiting
      Site JP81001
      Kashiwa, Chiba, Japan
      Withdrawn
      Site TW88604
      Tainan, East District, Taiwan, Province of China, 70457
      Withdrawn
      Site TW88606
      Taoyuan, Guishan District, Taiwan, Province of China, 83301
      Active, not recruiting
      Site KR82004
      Seoul, Seoul, Republic of Korea, 138-736
      Withdrawn
      Site FR33011
      Dijon, Dijon Cedex, France, 21079
      Completed
      MultiCare Regional Cancer Center - Gig Harbor
      Gig Harbor, WA, United States, 98335
      Completed
      Site FR33014
      Plerin, Plerin, France, 22190
      Completed
      Site JP81010
      Osaka, Osaka, Japan
      Completed
      Site AU61005
      Fitzroy, Victoria, Australia, 5XRF+WX
      Completed
      Site JP81012
      Chuo-ku, Tokyo, Japan
      Withdrawn
      Cancer Treatment Centers of America at Eastern Regional Medical Center
      Philadelphia, PA, United States, 19124
      Withdrawn
      Site TW88605
      Taipei City, Taiwan, Taiwan, Province of China, 2GR9+7H
      Completed
      Roswell Park Cancer Institute
      Buffalo, NY, United States, 14203
      Completed
      Site AU61006
      Warrnambool, Victoria, Australia, VIC 3280
      Active, not recruiting
      Site FR33002
      Grenoble, France
      Active, not recruiting
      Midstate Medical Center
      Meriden, CT, United States, 06451
      Withdrawn
      Site ES34011
      A Coruna, Galicia, Spain, 15009
      Active, not recruiting
      Site FR33007
      Strasbourg, Strasbourg, France, 67000
      Active, not recruiting
      Site JP81013
      Mitaka, Tokyo, Japan
      Withdrawn
      Site TW88603
      Tainan City, Taiwan, Taiwan, Province of China, 26CC+4Q
      Active, not recruiting
      Site FR33012
      Herblain, Herblain Cedex, France, 44805
      Active, not recruiting
      St. Joseph Heritage Medical Group
      Fullerton, CA, United States, 92835
      Active, not recruiting
      Site FR33005
      Pringy Cedex, France, 74374
      Active, not recruiting
      Site ES34003
      Pamplona, Navarra, Spain, 31008
      Active, not recruiting
      Site TW88601
      Taipei City, Taiwan, Taiwan, Province of China, 4G9C+W3
      Completed
      Site FR33016
      La Chaussee Saint Victor, Loir-et-Cher, France, 41260
      Withdrawn
      Site ES34002
      Girona, Spain, 17007
      Withdrawn
      The University of Chicago
      Chicago, IL, United States, 60637
      Active, not recruiting
      Site FR33013
      Villejuif, Villejuif Cedex, France, 94805
      Completed
      Site IT39006
      Rozzano, Milan, Italy, 20089
      Withdrawn
      Site IE35303
      Cork, Cork, Ireland, T12 DV56
      Active, not recruiting
      Site TW88602
      Taichung City, Taiwan, Taiwan, Province of China, 5M5J+36
      Completed
      Site FR33001
      Bayonne Cedex, France, 64109
      Completed
      Site ES34010
      Barcelona, Barcelona, Spain, 08028
      Completed
      Cancer Treatment Centers of Atlanta
      Newnan, GA, United States, 30265
      Withdrawn
      Site ES34001
      Sabadell, Barcelona, Spain, 8208
      Withdrawn
      Site AU61002
      North Adelaide, South Australia, Australia, 5006
      Completed
      Utah Cancer Specialists
      Salt Lake City, UT, United States, 84106
      Active, not recruiting
      Site JP81002
      Shinjuku-ku, Tokyo, Japan
      Completed
      Site JP81003
      Kashihara, Nara, Japan
      Withdrawn
      Site JP81008
      Suita, Osaka, Japan
      Completed
      Site JP81009
      Wakayama, Wakayama, Japan
      Completed
      Site JP81014
      Koto-ku, Tokyo, Japan
      Active, not recruiting
      Site JP81015
      Ube, Yamaguchi, Japan
      Withdrawn
      Oncology Consultants PA
      Houston, Texas, United States, 77024
      Completed
      Site KR82008
      Suwon-si, Gyeonggi-do, Republic of Korea
      Completed
      Site TR90003
      Diyarbakir, Turkey
      Completed
      Site TR90004
      Ankara, Turkey
      Completed
      Site TR90006
      Ankara, Turkey
      Active, not recruiting
      Site CN86013
      Shanghai, China
      Active, not recruiting
      Site CN86001
      Beijing, China
      Active, not recruiting
      Site CN86003
      Zhejiang, China
      Active, not recruiting
      Site CN86002
      Hubei, China
      Completed
      Site CN86007
      Tianjin, China
      Active, not recruiting
      Site CN86006
      Shanghai, China
      Completed
      Site CN86008
      Beijing, China
      Completed
      Site TR90002
      Istanbul, Turkey
      Completed
      Vista Oncology
      Olympia, Washington, United States, 98502
      Withdrawn
      Site TR90005
      Istanbul, Turkey
      Completed
      Site TR90001
      Konya, Turkey
      Completed
      Site IT39008
      Veneto, Italy
      Completed
      Site FR33019
      Roche-Sur-Yon, France
      Withdrawn
      Site FR33020
      Lyon Cedex, France
      Active, not recruiting
      Site CN86024
      Shan Xi, China
      Active, not recruiting
      Site IT39010
      Lombardia, Italy
      Completed
      Site CN86011
      Jiangsu, China
      Completed
      Site CN86018
      Zhejiang, China
      Active, not recruiting
      Site KR82010
      Daegu, Republic of Korea
      Completed
      Site KR82011
      Jeollanam-do, Republic of Korea
      Withdrawn
      Site IT39012
      Lazio, Italy
      Completed
      Site CN86020
      Guangdong, China
      Active, not recruiting
      Site IT39014
      Toscana, Italy
      Completed
      Site CN86005
      Jiangsu, China
      Active, not recruiting
      Site CN86004
      Guangdong, China
      Active, not recruiting
      Site CN86010
      Zhengzhou, China
      Completed
      Site CN86025
      Jiangsu, China
      Completed
      Site FR33018
      Bordeaux, France
      Completed
      Site KR82009
      Gyeonggi-do, Republic of Korea
      Active, not recruiting
      Site FR33023
      Pierre Benite, France
      Active, not recruiting
      Site CN86012
      Harbin, China
      Completed
      Site CN86014
      Beijing, China
      Active, not recruiting
      Virginia Mason
      Seattle, Washington, United States, 98101
      Active, not recruiting
      Site MX52003
      San Luis Potosi, Mexico
      Withdrawn
      Site CN86017
      Shijiazhuang, China
      Completed
      Norton Cancer Institute (NCI)
      Louisville, Kentucky, United States, 40202
      Withdrawn
      Site ES34020
      Madrid, Spain
      Withdrawn
      Site IT39009
      Ancona, Italy
      Completed
      Site CN86019
      Shanghai, China
      Completed
      Site TW88608
      New Taipei City, Taiwan, Province of China
      Active, not recruiting
      Site TW88609
      Taipei City, Taiwan, Province of China
      Active, not recruiting
      Site CN86022
      Xinjiang, China
      Completed
      Site CN86023
      Shandong, China
      Withdrawn
      Site BR55003
      Itajai, Brazil
      Active, not recruiting
      Site BR55004
      Santa Catarina, Brazil
      Completed
      Site BR55008
      Rio Grande do Sul, Brazil
      Active, not recruiting
      Site MX52004
      Distrito Federal, Mexico
      Active, not recruiting
      Site MX52005
      Veracruz, Mexico
      Active, not recruiting
      Site CN86009
      Chongqing, China
      Completed
      Site CN86016
      Guangzhou, China
      Active, not recruiting
      Site CN86026
      Changchun, China
      Active, not recruiting
      Site FR33021
      Nice Cedex 2, France
      Completed
      Site ES34021
      Barcelona, Spain
      Completed
      Memorial Sloan Kettering Bergen
      Montvale, New Jersey, United States, 07645
      Completed
      Memorial Sloan Kettering Commack
      Commack, New York, United States, 11725
      Active, not recruiting
      Memorial Sloan Kettering Basking Ridge
      Basking Ridge, New Jersey, United States, 07920
      Completed
      Memorial Sloan Kettering Westchester
      West Harrison, New York, United States, 10604
      Active, not recruiting
      Memorial Sloan Kettering Nassau
      Uniondale, New York, United States, 11553
      Withdrawn
      Memorial Sloan Kettering Monmouth
      Middletown, New Jersey, United States, 07748
      Withdrawn
      Holden Comprehensive Cancer Center
      Iowa City, Iowa, United States, 52242
      Withdrawn
      Inova Dwight and Martha Schar
      Fairfax, Virginia, United States, 22031
      Completed
      Site ES34018
      Barcelona, Spain
      Withdrawn
      Site BR55001
      Sao Paulo, Brazil
      Withdrawn
      Hoag Hospital
      Newport Beach, CA, United States, 92663
      Withdrawn
      Site BR55002
      Porto Alegre, Brazil
      Withdrawn
      Site BR55006
      Sao Paulo, Brazil
      Withdrawn
      Site IT39015
      Bologna, Italy
      Completed
      University of Illinois at Chicago
      Chicago, IL, United States, 60612
      Completed
      Site ES34017
      Santiago de Compostela, Spain
      Active, not recruiting
      Site ES34026
      Malaga, Spain
      Completed
      Site ES34024
      Santander, Spain
      Withdrawn
      Site ES34025
      Castello de la plana, Spain
      Completed
      Novant Health Presbyterian Medical Center
      Charlotte, North Carolina, United States, 28204
      Completed
      Novant Health
      Winston-Salem, North Carolina, United States, 27103
      Withdrawn
      St Vincent's Frontier Cancer Center
      Billings, Montana, United States, 59102
      Completed
      Site ES34022
      Cordoba, Spain
      Completed
      Site BR55009
      Centro Passo Fundo, Brazil
      Active, not recruiting
      Site BR55010
      Sao Paulo, Brazil
      Active, not recruiting
      Site BR55011
      Sao Paulo, Brazil
      Withdrawn
      Site ES34019
      Zaragoza, Spain
      Completed
      Site BR55012
      Porto Alegre, Rio Grande Do Sul, Brazil

      Frequently Asked Questions

      Are clinical trials only for people with advanced cancer?

      While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

      Will I have to stop my current treatment to participate in a clinical trial?

      Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

      Should I be worried about getting a placebo?

      In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

      Do I need a referral from my doctor to take part in a study?

      Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

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