Study summary

This study will test an experimental drug (enfortumab vedotin) alone and with different combinations of anticancer therapies. Pembrolizumab is an immune checkpoint inhibitor (CPI) that is used to treat patients with cancer of the urinary system (urothelial cancer). This type of cancer includes cancer of the bladder, renal pelvis, ureter or urethra. Some parts of the study will look at locally advanced or metastatic urothelial cancer (la/mUC), which means the cancer has spread to nearby tissues or to other areas of the body. Other parts of the study will look at muscle-invasive bladder cancer (MIBC), which is cancer at an earlier stage that has spread into the muscle wall of the bladder. This study will look at the side effects of enfortumab vedotin alone and with other anticancer therapies. A side effect is a response to a drug that is not part of the treatment effect. This study will also test if the cancer shrinks with the different treatment combinations.

Additional Study Details

Phase
Phase 1/Phase 2
Product
enfortumab vedotin (EV)
pembrolizumab
cisplatin
carboplatin
gemcitabine
Product
N/A
Type
Interventional
Masking
None (Open Label)
Enrollment number
457
Show Additional Study Details

Get more information

Would you like more information about clinical trial sites that are recruiting participants for A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer? Contact us by filling out your information to the right and we’ll respond to you.

  • A caregiver
  • A healthcare provider
  • A parent
  • A patient
  • A patient advocate
  • Algeria
  • Argentina
  • Armenia
  • Australia
  • Austria
  • Belarus
  • Belgium
  • Bosnia And Herzegovina
  • Brazil
  • Bulgaria
  • Canada
  • Chile
  • China
  • Colombia
  • Croatia
  • Czech Republic
  • Denmark
  • Dominican Republic
  • Egypt
  • Estonia
  • Finland
  • Former Serbia and Montenegro
  • France
  • Georgia
  • Germany
  • Greece
  • Guatemala
  • Hong Kong
  • Hungary
  • Iceland
  • India
  • Indonesia
  • Ireland
  • Israel
  • Italy
  • Japan
  • Jordan
  • Kazakhstan
  • Latvia
  • Lebanon
  • Lithuania
  • Macedonia
  • Malaysia
  • Mexico
  • Montenegro
  • Morocco
  • Netherlands
  • New Zealand
  • Norway
  • Panama
  • Peru
  • Philippines
  • Poland
  • Portugal
  • Puerto Rico
  • Republic of Korea
  • Republic of Moldova
  • Romania
  • Russian Federation
  • Saudi Arabia
  • Serbia
  • Singapore
  • Slovakia
  • Slovenia
  • South Africa
  • Spain
  • Sweden
  • Switzerland
  • Taiwan, Province of China
  • Thailand
  • Turkey
  • Ukraine
  • United Kingdom
  • United States
  • Vietnam

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    Locations

    Contact Us
    Contact Us
    Recruiting
    University of Virginia
    Charlottesville, VA, United States, 22903
    Recruiting
    Medical College of Wisconsin (Milwaukee)
    Milwaukee, WI, United States, 53226
    Recruiting
    Winship Cancer Institute / Emory University School of Medicine
    Atlanta, GA, United States, 30322
    Recruiting
    Nebraska Hematology Oncology P.C.
    Lincoln, NE, United States, 68506
    Recruiting
    Gabrail Cancer Center Research, LLC
    Canton, OH, United States, 44718
    Recruiting
    Roswell Park Cancer Institute
    Buffalo, NY, United States, 14263
    Recruiting
    Weill Cornell Medical College
    New York, NY, United States, 10065
    Recruiting
    University of Miami
    Miami, FL, United States, 33136
    Recruiting
    Highlands Oncology Group
    Fayetteville, AR, United States, 72703
    Recruiting
    Levine Cancer Institute
    Charlotte, NC, United States, 28204
    Recruiting
    Henry Ford Health System
    Detroit, MI, United States, 48202
    Recruiting
    University of Chicago Medical Center
    Chicago, IL, United States, 60637-1470
    Recruiting
    University of Minnesota
    Minneapolis, MN, United States, 55455
    Recruiting
    Kaiser Permanente Southern California
    Woodland Hills, CA, United States, 91367
    Recruiting
    Medical University of South Carolina/Hollings Cancer Center
    Charleston, SC, United States, 29425
    Recruiting
    Arizona Oncology Associates, PC - HOPE
    Tucson, AZ, United States, 85710
    Recruiting
    University of Kansas Cancer Center
    Westwood, KS, United States, 66205
    Recruiting
    Tulane University Hospital and Clinic
    New Orleans, LA, United States, 70112
    Recruiting
    Stanford Cancer Center / Blood & Marrow Transplant Program
    Stanford, CA, United States, 94305
    Recruiting
    Cardinal Bernardin Cancer Center / Loyola University Medical Center
    Maywood, IL, United States, 60153
    Recruiting
    Yale Cancer Center
    New Haven, CT, United States, 06520
    Recruiting
    Rocky Mountain Cancer Centers - Aurora
    Aurora, CO, United States, 80012
    Recruiting
    University of California at San Francisco
    San Francisco, CA, United States, 94134
    Recruiting
    Memorial Sloan Kettering Cancer Center
    New York, NY, United States, 10087-9049
    Recruiting
    New York University (NYU) Cancer Institute
    New York, NY, United States, 10016
    Recruiting
    Allegheny General Hospital
    Pittsburgh, PA, United States, 15212
    Recruiting
    Piedmont Cancer Institute
    Atlanta, GA, United States, 30309
    Recruiting
    Banner MD Anderson Cancer Center
    Gilbert, AZ, United States, 85234
    Recruiting
    Hackensack University Medical Center
    Hackensack, NJ, United States, 07601
    Recruiting
    University of Colorado Hospital / University of Colorado
    Aurora, CO, United States, 80045-0510
    Recruiting
    University of Michigan Comprehensive Cancer Center
    Ann Arbor, MI, United States, 48109
    Recruiting
    University of California Irvine - Newport
    Orange, CA, United States, 92868
    Recruiting
    Carolina Urologic Research Center
    Myrtle Beach, SC, United States, 29572
    Recruiting
    UNC Lineberger Comprehensive Cancer Center / University of North Carolina
    Chapel Hill, NC, United States, 27599
    Recruiting
    University of Texas Health Science Center at San Antonio
    San Antonio, TX, United States, 78229
    Completed
    Alaska Urological Institute
    Anchorage, AK, United States, 99503
    Recruiting
    UC San Diego / Moores Cancer Center
    La Jolla, CA, United States, 92093
    Recruiting
    Saint Joseph Heritage Medical Group
    Santa Rosa, CA, United States, 95403
    Recruiting
    University of New Mexico Cancer Center
    Albuquerque, NM, United States, 87106
    Recruiting
    Decatur Memorial Hospital - Illinois
    Decatur, IL, United States, 62526
    Recruiting
    Case Western Reserve University / University Hospitals Case Medical Center
    Cleveland, OH, United States, 44106
    Recruiting
    University of California, Davis Comprehensive Cancer Center
    Sacramento, CA, United States, 95817
    Recruiting
    Penn State Milton S. Hershey Medical Center
    Hershey, PA, United States, 17033
    Recruiting
    Utah Cancer Specialists
    Salt Lake City, UT, United States, 84106
    Recruiting
    Northwestern Medicine Cancer Center Delnor
    Geneva, IL, United States, 60134
    Recruiting
    McLaren Greater Lansing Hospital
    Lansing, MI, United States, 48910
    Recruiting
    OptumCare Cancer Center
    Las Vegas, NV, United States, 89102
    Recruiting
    University of Mississippi Medical Center
    Jackson, MS, United States, 39213
    Recruiting
    Mayo Clinic Arizona
    Phoenix, AZ, United States, 85054
    Recruiting
    University of Rochester Medical Center
    Rochester, NY, United States, 14642
    Recruiting
    Fox Chase Cancer Center
    Philadelphia, PA, United States, 19111
    Recruiting
    Mayo Clinic Florida
    Jacksonville, FL, United States, 32224
    Recruiting
    Georgetown University Medical Center
    Washington, DC, United States, 20007
    Recruiting
    Medical Oncology Associates
    Spokane, WA, United States, 99208
    Recruiting
    Ochsner Clinic Foundation
    New Orleans, LA, United States, 70121
    Recruiting
    Boca Raton Regional Hospital / Lynn Cancer Institute
    Boca Raton, FL, United States, 33486
    Recruiting
    Washington University School of Medicine - Siteman Cancer Center
    Saint Louis, Mo, United States, 63110
    Recruiting
    Tower Hematology Oncology Medical Group
    Beverly Hills, CA, United States, 90211
    Recruiting
    Southcoast Centers for Cancer Care - Fairhaven Site
    Fairhaven, MA, United States, 02719
    Recruiting
    Northwestern Medicine Cancer Center - Kishwaukee / Kishwaukee Cancer Center
    DeKalb, IL, United States, 60115
    Recruiting
    Northwestern Medicine Cancer Center - Warrenville / Central DuPage Hospital - Cancer Care
    Warrenville, IL, United States, 60555
    Recruiting
    Memorial Sloan Kettering Cancer Center - Bergen
    Montvale, NJ, United States, 07645
    Recruiting
    Memorial Sloan Kettering Cancer Center - Commack
    Commack, NY, United States, 11725
    Recruiting
    Memorial Sloan Kettering Cancer Center - Monmouth
    Middletown, NJ, United States, 07748
    Recruiting
    Memorial Sloan Kettering Cancer Center - Nassau
    Uniondale, NY, United States, 11553
    Recruiting
    Memorial Sloan Kettering Cancer Center - Westchester
    West Harrison, NY, United States, 10604
    Recruiting
    Memorial Sloan Kettering Cancer Center - Basking Ridge
    Basking Ridge, NJ, United States, 07920
    Recruiting
    Sarah Cannon Research Institute
    Chattanooga, TN, United States, 37404
    Completed
    Tennessee Oncology / Sarah Cannon Research Institute
    Nashville, TN, United States, 37203
    Recruiting
    Toledo Clinic Cancer Center
    Toledo, OH, United States, 43623
    Recruiting
    Eastern CT Hematology and Oncology Associates
    Norwich, CT, United States, 06360
    Recruiting
    Saint Francis Hospital Cancer Center
    Greenville, SC, United States, 29607
    Recruiting
    Vidant Medical Center
    Greenville, NC, United States, 27834
    Recruiting
    Texas Oncology - Fort Worth Cancer Center
    Fort Worth, TX, United States, 76104
    Recruiting
    Texas Oncology - Tyler
    Tyler, TX, United States, 75702
    Recruiting
    Site CA11005
    Montreal, Quebec, Canada, H3T1E2
    Recruiting
    CMOH Broomall
    Broomall, PA, United States, 19008
    Recruiting
    New York Oncology Hematology, P.C.
    Albany, NY, United States, 12206
    Recruiting
    NYU Winthrop Hospital
    Mineola, NY, United States, 11501
    Recruiting
    Site CA11002
    Sherbrooke, Quebec, Canada, J1H 5N4
    Recruiting
    Northwell Cancer Center / Monter Cancer Center
    Lake Success, NY, United States, 11042
    Recruiting
    Site CA11011
    Kingston, Ontario, Canada, K7L 2V7
    Recruiting
    Holy Cross Hospital - Michael and Dianne Bienes Comprehensive Cancer Center
    Fort Lauderdale, FL, United States, 33308
    Recruiting
    Maryland Oncology Hematology, P.A.
    Silver Spring, MD, United States, 20904
    Recruiting
    Site CA11013
    Montreal, Quebec, Canada, H4A3J1
    Recruiting
    Site CA11001
    Toronto, Ontario, Canada, M5G 2M9
    Recruiting
    Site CA11008
    East Brampton, Ontario, Canada, L6R 3J7
    Recruiting
    Duke University Medical Center
    Durham, NC, United States, 27710
    Recruiting
    Site FR33001
    Strasbourg, France, 67200
    Recruiting
    Site FR33002
    Nice Cedex, France, 06189
    Recruiting
    Site FR33003
    Lyon, France, 69008
    Recruiting
    Site FR33008
    Bordeaux, France, 33000
    Recruiting
    Site PR78701
    Rio Piedras, Puerto Rico, 00935

    Frequently Asked Questions

    Are clinical trials only for people with advanced cancer?

    While some clinical trials may focus on more advanced cancers, many trials are open to patients at various stages of their cancer. Each study has rules about who can take part. For example, only patients in a certain age group or those who have a certain type of tumor may be able to join.

    Will I have to stop my current treatment to participate in a clinical trial?

    Sometimes researchers want participants to keep taking their current treatments during a clinical trial. Other times, you may need to stop your current treatments for a while. If the investigational treatment doesn't work, you can usually go back to your original treatment plan.

    Should I be worried about getting a placebo?

    In cancer clinical trials, a placebo is only used if there is no other treatment for that type of cancer. This helps compare an investigational treatment to the placebo. Placebos are rarely used in cancer trials because the best available treatment, called the “standard of care”, is usually given instead.

    Do I need a referral from my doctor to take part in a study?

    Your doctor may not know about all the opportunities for clinical trials that are available to you. Talk to your doctor or other medical provider about clinical trial information that you find. They can help you decide if a clinical trial is right for you. If you do not find any options on this website, we recommend you visit an online public registry website like clinicaltrials.gov to see a wide variety of available clinical trials.

    Explore More

    1

    What are clinical trials?

    2

    Why are Clinical Trials Important?

    3

    Why Participate in a Clinical Trial?